MEIS2

Across TCGA patient cohorts, MEIS2 protein abundance is significantly associated with the RNA expression of many other genes, with 2,383 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible MEIS2-associated genes across cancer lineages are ADGRB2, TRPC1, and DIRAS1. Each is linked with MEIS2 in more than 1 cancer types. Because this analysis shows association rather than direction, both MEIS2-to-partner and partner-to-MEIS2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, MEIS2 versus ADGRB2 in LSCC, with a Pearson correlation of 0.68.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MEIS2→partner) and Y-score (partner→MEIS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ADGRB2 →	+1.550	+1.493	.006	.004	3	2
LSCC	TRPC1 →	+1.874	+1.215	<.001	<.001	3	2
LSCC	DIRAS1 →	+1.671	+1.178	.006	.003	3	2
UCEC	CCDC184 →	+0.715	+0.624	<.001	.003	3	2
GBM	RNY4P24 →	-1.301	-0.762	.003	.006	3	2
UCEC	BIK →	+0.731	+0.499	.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,383 associations by consensus.

MEIS2 vs ADGRB2 — LSCC

Explore this scatter interactively →