MEIS2

Across TCGA pan-cancer cohorts, MEIS2 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of MEIS2’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where MEIS2 RNA is repressed in tumor relative to normal tissue. In most cancer types MEIS2 is over-expressed in tumor, although a few such as KIRC and KIRP show the opposite, repressed pattern.

KIRC, KIRP, and COAD are the cancer types where MEIS2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MEIS2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	IV	−0.914	<.001	10	view →
KIRP	Female	All	−1.391	<.001	9	view →
COAD	All	II,III,IV	−0.914	<.001	9	view →
KICH	Female	All	−2.436	<.001	8	view →
UCEC	All	All	−2.468	<.001	6	view →
BRCA	All	All	−1.300	<.001	6	view →
LUAD	Female	III,IV	−1.016	<.001	6	view →
THCA	All	All	−0.520	<.001	6	view →
BLCA	All	IV	−1.650	.005	5	view →
READ	All	All	−1.776	.002	4	view →
STAD	Female	All	−1.760	<.001	4	view →
LIHC	All	All	+0.559	<.001	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

MEIS2–KIRC

Open the KIRC breakdown →