MEIS2

Across TCGA patient cohorts, MEIS2 mutation is significantly associated with the RNA expression of many other genes, with 5,430 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MEIS2-associated genes across cancer lineages are CENPM, MCM5, and MED31. Each is linked with MEIS2 in more than 3 cancer types. Because this analysis shows association rather than direction, both MEIS2-to-partner and partner-to-MEIS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CENPM grouped by MEIS2-low versus MEIS2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MEIS2→partner) and Y-score (partner→MEIS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CENPM →	+0.628	+1.784	<.001	<.001	3	3
UCEC	MCM5 →	+0.479	+2.828	<.001	.001	3	3
UCEC	MED31 →	+0.454	+2.269	<.001	<.001	3	3
UCEC	PDHX →	+0.557	+2.301	<.001	<.001	3	3
UCEC	HAUS8 →	+0.400	+2.000	<.001	<.001	3	3
UCEC	LDHA →	+0.549	+2.000	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,430 associations by consensus.

CENPM by MEIS2 expression — UCEC

Explore this box plot interactively →