MEIS2

Across TCGA patient cohorts, MEIS2 mutation is significantly associated with the total protein of many other genes, with 55 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MEIS2-associated genes across cancer lineages are ERK2, ATM, and Caspase-7-cleavedD198. Each is linked with MEIS2 in more than 2 cancer types. Because this analysis shows association rather than direction, both MEIS2-to-partner and partner-to-MEIS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by MEIS2-low versus MEIS2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MEIS2→partner) and Y-score (partner→MEIS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.174	+2.415	.002	.002	3	3
UCEC	ATM →	-0.452	-1.378	<.001	.008	3	3
UCEC	Caspase-7-cleavedD198 →	+0.608	+1.847	<.001	.007	3	3
SKCM	FOXO3a →	-0.129	-3.000	.025	.035	3	2
UCEC	14-3-3_beta →	-0.078	-1.973	.009	.008	3	2
UCEC	eEF2 →	+0.273	+1.378	.010	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 55 associations by consensus.

ERK2 by MEIS2 expression — UCEC

Explore this box plot interactively →