MEIS2

Across TCGA cell cohorts, MEIS2 mutation is significantly associated with the RNA expression of many other genes, with 51 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MEIS2-associated genes across cancer lineages are ZAN, PSKH2, and CCL19. Each is linked with MEIS2 in more than 1 cancer types. Because this analysis shows association rather than direction, both MEIS2-to-partner and partner-to-MEIS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZAN grouped by MEIS2-low versus MEIS2-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MEIS2→partner) and Y-score (partner→MEIS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	ZAN →	+0.006	+5.662	<.001	.002	3	1
LUNG_NSCLC_LUAD	PSKH2 →	+0.024	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	CCL19 →	+0.121	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	TXNDC8 →	+0.006	+5.228	<.001	.005	3	1
LARGE_INTESTINE	ZBED4 →	+0.614	+3.137	.003	.007	3	1
LARGE_INTESTINE	SNPH →	+0.807	+3.215	.005	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

ZAN by MEIS2 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →