MEIS1-AS2

Across TCGA pan-cancer cohorts, MEIS1-AS2 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated MEIS1-AS2 data layer.

The strongest signal is observed in thyroid carcinoma (THCA), where higher MEIS1-AS2 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated MEIS1-AS2 expression acts as an unfavorable survival marker, although some lineages such as ACC and UCS show a favorable association.

THCA, ACC, and UCS are the cancer types where MEIS1-AS2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THCA	DFS	Median	II,III,IV	0.764	0.885	.002	83	view →
ACC	OS	Median	All	0.782	0.466	.001	80	view →
UCS	OS	Tertile	II,III,IV	0.718	0.218	.001	70	view →
KIRP	DFS	Quartile	All	0.735	0.921	<.001	70	view →
OV	OS	Quartile	All	0.879	0.752	.006	54	view →
LGG	OS	Median	All	0.722	0.884	<.001	51	view →
LUAD	DFS	Quartile	III,IV	0.768	0.299	.001	51	view →
LAML	DFS	Tertile	All	0.268	0.555	.001	28	view →
UVM	OS	Tertile	II,III,IV	0.646	0.900	.004	24	view →
KIRC	OS	Median	All	0.564	0.677	.012	21	view →
HNSC	DFS	Quartile	All	0.790	0.682	.013	21	view →
SARC	DFS	Tertile	All	0.445	0.238	.006	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

MEIS1-AS2–THCA (DFS)

Open the THCA breakdown →