MEIS1-AS2

Across TCGA pan-cancer cohorts, MEIS1-AS2 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of MEIS1-AS2’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where MEIS1-AS2 RNA is repressed in tumor relative to normal tissue. In most cancer types MEIS1-AS2 is over-expressed in tumor, although a few such as KIRP and LUSC show the opposite, repressed pattern.

KIRP, LUSC, and THCA are the cancer types where MEIS1-AS2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MEIS1-AS2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	Male	All	−0.149	<.001	8	view →
LUSC	Male	All	−0.134	.003	6	view →
THCA	Female	All	−0.091	<.001	5	view →
STAD	All	II,III,IV	−0.300	.015	4	view →
BRCA	All	III,IV	−0.114	.002	4	view →
COAD	All	II,III,IV	−0.111	.014	3	view →
PAAD	Female	All	−0.475	.001	2	view →
LUAD	All	III,IV	−0.196	<.001	2	view →
READ	Male	All	−0.116	.038	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

MEIS1-AS2–KIRP

Open the KIRP breakdown →