MEIOC

Across TCGA cell cohorts, MEIOC mutation is significantly associated with the RNA expression of many other genes, with 248 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MEIOC-associated genes across cancer lineages are OR2AK2, C1orf146, and OR52E6. Each is linked with MEIOC in more than 1 cancer types. Because this analysis shows association rather than direction, both MEIOC-to-partner and partner-to-MEIOC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2AK2 grouped by MEIOC-low versus MEIOC-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MEIOC→partner) and Y-score (partner→MEIOC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	OR2AK2 →	+0.073	+4.029	<.001	.009	3	2
OVARY	C1orf146 →	+0.032	+4.450	.003	.004	3	2
LUNG_NSCLC_LUAD	OR52E6 →	+0.206	+4.887	<.001	.009	3	2
OVARY	OR2M4 →	+0.070	+4.700	<.001	.002	3	1
OVARY	PNLIPRP1 →	+0.029	+4.450	<.001	.004	3	1
OVARY	OR2H1 →	+0.019	+4.029	.003	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 248 associations by consensus.

OR2AK2 by MEIOC expression — OVARY

Explore this box plot interactively →