MEIOB

Across TCGA patient cohorts, MEIOB mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MEIOB-associated genes across cancer lineages are GAPDH, MEK1, and mTOR. Each is linked with MEIOB in more than 1 cancer types. Because this analysis shows association rather than direction, both MEIOB-to-partner and partner-to-MEIOB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by MEIOB-low versus MEIOB-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MEIOB→partner) and Y-score (partner→MEIOB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GAPDH →	+0.628	+3.169	.007	.018	3	1
UCEC	MEK1 →	+0.385	+2.115	.016	.019	3	1
UCEC	mTOR →	-0.163	-2.115	.021	.019	3	1
UCEC	p62 Lck ligand →	+0.378	+2.469	.007	.010	3	1
UCEC	PDK1_pS241 →	+0.162	+1.598	.030	.044	3	1
UCEC	Rad50 →	-0.270	-2.115	.010	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

GAPDH by MEIOB expression — UCEC

Explore this box plot interactively →