MEGF8

Across TCGA cell cohorts, MEGF8 mutation is significantly associated with the RNA expression of many other genes, with 1,993 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MEGF8-associated genes across cancer lineages are PYDC2, PES1, and CENPM. Each is linked with MEGF8 in more than 1 cancer types. Because this analysis shows association rather than direction, both MEGF8-to-partner and partner-to-MEGF8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PYDC2 grouped by MEGF8-low versus MEGF8-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MEGF8→partner) and Y-score (partner→MEGF8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	PYDC2 →	+0.122	+4.058	<.001	.007	3	2
LARGE_INTESTINE	PES1 →	+0.444	+2.122	.003	.001	3	2
LARGE_INTESTINE	CENPM →	+0.776	+3.459	<.001	.001	3	2
LARGE_INTESTINE	TRMU →	+0.736	+2.700	<.001	<.001	3	2
LARGE_INTESTINE	STUB1 →	+0.321	+3.459	.006	.001	3	2
LARGE_INTESTINE	FCGRT →	-2.622	-2.371	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,993 associations by consensus.

PYDC2 by MEGF8 expression — LUNG_SCLC

Explore this box plot interactively →