MEF2D

Across TCGA patient cohorts, MEF2D mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MEF2D-associated genes across cancer lineages are VHL, 14-3-3_beta, and EGFR_pY1068. Each is linked with MEF2D in more than 1 cancer types. Because this analysis shows association rather than direction, both MEF2D-to-partner and partner-to-MEF2D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VHL grouped by MEF2D-low versus MEF2D-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MEF2D→partner) and Y-score (partner→MEF2D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	VHL →	-0.616	-2.000	.007	.009	3	2
UCEC	14-3-3_beta →	-0.075	-1.847	.028	.049	3	1
UCEC	EGFR_pY1068 →	-0.196	-1.247	.022	.045	3	1
UCEC	A-Raf_pS299 →	-0.114	-2.222	.004	.010	3	1
UCEC	ERK2 →	+0.133	+1.514	.043	.015	3	1
UCEC	HER2_pY1248 →	-0.180	-2.523	.048	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

VHL by MEF2D expression — UCEC

Explore this box plot interactively →