MEF2C

Across TCGA patient cohorts, MEF2C mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MEF2C-associated genes across cancer lineages are MEK1, PCNA, and ATM. Each is linked with MEF2C in more than 1 cancer types. Because this analysis shows association rather than direction, both MEF2C-to-partner and partner-to-MEF2C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by MEF2C-low versus MEF2C-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MEF2C→partner) and Y-score (partner→MEF2C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.429	+2.050	<.001	<.001	3	2
UCEC	PCNA →	+0.186	+2.247	.003	.001	3	2
UCEC	ATM →	-0.493	-2.074	<.001	.004	3	2
UCEC	Caspase-7-cleavedD198 →	+0.440	+1.434	.012	.027	3	2
LUSC	Chk2 →	+0.305	+2.816	.042	.036	2	2
LUSC	Dvl3 →	+0.236	+2.816	.028	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

MEK1 by MEF2C expression — UCEC

Explore this box plot interactively →