MEF2C

Across TCGA cell cohorts, MEF2C RNA expression is significantly associated with the go_rna of many other GO terms, with 4,960 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MEF2C-associated GO terms across cancer lineages are Regulation of synaptic activity, Cardiac ventricle formation, and AMPA selective glutamate receptor signaling pathway. Each is linked with MEF2C in more than 15 cancer types. Because this analysis shows association rather than direction, both MEF2C-to-partner and partner-to-MEF2C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of synaptic activity grouped by MEF2C-low versus MEF2C-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MEF2C→partner) and Y-score (partner→MEF2C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Regulation of synaptic activity →	+1.438	+3.134	<.001	<.001	3	16
BLOOD_Leukemia	Cardiac ventricle formation →	+1.637	+4.293	<.001	<.001	3	15
CNS	AMPA selective glutamate receptor signaling pathway →	+1.254	+1.732	<.001	<.001	3	11
BLOOD_Leukemia	Primary heart field specification →	+1.399	+4.079	<.001	<.001	3	11
LIVER	NMDA selective glutamate receptor signaling pathway →	-0.245	-2.177	<.001	<.001	3	10
OESOPHAGUS	Negative regulation of vascular associated smooth muscle cell migration →	-0.236	-1.647	.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,960 associations by consensus.

Regulation of synaptic activity by MEF2C expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →