MEF2A

Across TCGA patient cohorts, MEF2A mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MEF2A-associated genes across cancer lineages are VHL, Caspase-7-cleavedD198, and 14-3-3_beta. Each is linked with MEF2A in more than 1 cancer types. Because this analysis shows association rather than direction, both MEF2A-to-partner and partner-to-MEF2A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VHL grouped by MEF2A-low versus MEF2A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MEF2A→partner) and Y-score (partner→MEF2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	VHL →	-1.255	-3.807	<.001	<.001	3	2
UCEC	Caspase-7-cleavedD198 →	+0.660	+2.135	.003	.010	3	2
UCEC	14-3-3_beta →	-0.102	-3.432	.008	.005	3	1
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.407	+1.678	.037	.023	3	1
UCEC	JNK2 →	+0.220	+2.196	.003	.032	3	1
UCEC	MEK1 →	+0.460	+3.807	.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

VHL by MEF2A expression — UCEC

Explore this box plot interactively →