MEF2A

Across TCGA pan-cancer cohorts, MEF2A RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of MEF2A’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where MEF2A RNA is repressed in tumor relative to normal tissue. In most cancer types MEF2A is over-expressed in tumor, although a few such as LUSC and BLCA show the opposite, repressed pattern.

LUSC, BLCA, and HNSC are the cancer types where MEF2A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MEF2A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	All	III,IV	−1.158	<.001	8	view →
BLCA	Male	All	−0.908	.007	8	view →
HNSC	All	II,III,IV	+0.523	.001	8	view →
THCA	All	All	−0.472	<.001	8	view →
LUAD	Female	III,IV	−1.055	<.001	7	view →
UCEC	All	All	−1.355	<.001	6	view →
COAD	All	All	−0.438	<.001	6	view →
BRCA	Female	All	−0.284	<.001	6	view →
CHOL	All	All	+0.889	.011	2	view →
READ	All	All	−0.757	.007	2	view →
KIRP	Male	All	−0.481	.002	2	view →
PRAD	All	All	−0.391	.002	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

MEF2A–LUSC

Open the LUSC breakdown →