MEDAG

Across TCGA patient cohorts, MEDAG mutation is significantly associated with the RNA expression of many other genes, with 176 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MEDAG-associated genes across cancer lineages are RNA5SP146, RN7SL237P, and SLC25A27. Each is linked with MEDAG in more than 1 cancer types. Because this analysis shows association rather than direction, both MEDAG-to-partner and partner-to-MEDAG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP146 grouped by MEDAG-low versus MEDAG-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MEDAG→partner) and Y-score (partner→MEDAG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP146 →	+0.377	+2.677	<.001	.003	3	2
BLCA	RN7SL237P →	+0.302	+4.973	<.001	.009	3	2
UCEC	SLC25A27 →	-0.817	-3.451	.003	.005	3	1
UCEC	CACNA2D3 →	-0.744	-3.678	.007	.001	3	1
UCEC	SNRNP25 →	+0.460	+2.660	.009	.005	3	1
UCEC	AGBL2 →	-0.739	-3.700	.008	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 176 associations by consensus.

RNA5SP146 by MEDAG expression — UCEC

Explore this box plot interactively →