MEDAG

Across TCGA pan-cancer cohorts, MEDAG RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of MEDAG’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where MEDAG RNA is repressed in tumor relative to normal tissue. In most cancer types MEDAG is over-expressed in tumor, although a few such as KICH and BLCA show the opposite, repressed pattern.

KICH, BLCA, and UCEC are the cancer types where MEDAG tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MEDAG RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	All	III,IV	−2.814	<.001	10	view →
BLCA	Male	All	−2.426	<.001	7	view →
UCEC	All	III,IV	−3.746	<.001	6	view →
BRCA	All	III,IV	−2.154	<.001	6	view →
COAD	All	All	−0.575	.018	4	view →
HNSC	Female	III,IV	+1.486	.022	3	view →
CHOL	All	All	+1.434	.001	2	view →
KIRC	All	All	+0.479	.008	2	view →
LUAD	Female	II,III,IV	+0.851	.047	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

MEDAG–KICH

Open the KICH breakdown →