MEDAG

Across TCGA patient cohorts, MEDAG mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MEDAG-associated genes across cancer lineages are eIF4E, Notch1, and p62 Lck ligand. Each is linked with MEDAG in more than 1 cancer types. Because this analysis shows association rather than direction, both MEDAG-to-partner and partner-to-MEDAG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by MEDAG-low versus MEDAG-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MEDAG→partner) and Y-score (partner→MEDAG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.202	+2.820	.047	.035	3	1
UCEC	Notch1 →	+0.200	+2.179	.003	.034	3	1
UCEC	p62 Lck ligand →	+0.547	+3.584	<.001	.002	3	1
UCEC	Annexin-1 →	+0.817	+3.189	.001	.010	3	1
UCEC	Tuberin →	+0.429	+2.459	<.001	.020	3	1
UCEC	Caspase-8 →	-0.254	-3.143	.036	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

eIF4E by MEDAG expression — UCEC

Explore this box plot interactively →