MEDAG

Across TCGA cell cohorts, MEDAG mutation is significantly associated with the RNA expression of many other genes, with 30 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MEDAG-associated genes across cancer lineages are GHRH, RESP18, and OR2S2. Each is linked with MEDAG in more than 1 cancer types. Because this analysis shows association rather than direction, both MEDAG-to-partner and partner-to-MEDAG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GHRH grouped by MEDAG-low versus MEDAG-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MEDAG→partner) and Y-score (partner→MEDAG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	GHRH →	+0.145	+4.794	<.001	.001	3	1
STOMACH	RESP18 →	+0.030	+4.285	<.001	.007	3	1
STOMACH	OR2S2 →	+0.061	+4.432	<.001	.003	3	1
LARGE_INTESTINE	ATP23 →	+0.531	+3.364	.009	.002	3	1
LARGE_INTESTINE	CEP57L1 →	+0.563	+3.082	.008	.007	3	1
LARGE_INTESTINE	CTXND2 →	+0.020	+2.247	.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

GHRH by MEDAG expression — STOMACH

Explore this box plot interactively →