MED6

Across TCGA patient cohorts, MED6 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MED6-associated genes across cancer lineages are Notch1, ATM, and Di-Ras3. Each is linked with MED6 in more than 1 cancer types. Because this analysis shows association rather than direction, both MED6-to-partner and partner-to-MED6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by MED6-low versus MED6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MED6→partner) and Y-score (partner→MED6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.138	+3.009	.029	.019	3	2
UCEC	ATM →	-0.651	-2.700	.001	.006	3	2
UCEC	Di-Ras3 →	-0.165	-2.700	.013	.006	3	2
UCEC	eEF2 →	+0.418	+2.700	.009	.006	3	1
UCEC	EGFR_pY1068 →	-0.313	-2.700	.005	.006	3	1
UCEC	ERK2 →	+0.240	+2.000	.005	.032	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

Notch1 by MED6 expression — UCEC

Explore this box plot interactively →