MED6

Across TCGA pan-cancer cohorts, MED6 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of MED6’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where MED6 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MED6 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

HNSC, KIRP, and LIHC are the cancer types where MED6 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MED6 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+0.710	<.001	12	view →
KIRP	All	II,III,IV	+0.710	<.001	10	view →
LIHC	Male	II,III,IV	+0.854	<.001	9	view →
BLCA	All	All	+0.574	<.001	9	view →
KIRC	All	All	+0.334	<.001	9	view →
LUAD	Male	II,III,IV	+0.553	<.001	8	view →
THCA	Male	IV	−0.506	<.001	8	view →
LUSC	Male	II,III,IV	+0.599	<.001	7	view →
STAD	All	All	+0.464	<.001	6	view →
CHOL	Male	All	+1.271	<.001	5	view →
READ	All	II,III,IV	+0.409	<.001	5	view →
ESCA	All	All	+0.787	<.001	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

MED6–HNSC

Open the HNSC breakdown →