MED6

Across TCGA cell cohorts, MED6 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,292 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MED6-associated GO terms across cancer lineages are Monoubiquitinated protein deubiquitination, DNA-templated DNA replication, and Double-strand break repair via synthesis-dependent strand annealing. Each is linked with MED6 in more than 13 cancer types. Because this analysis shows association rather than direction, both MED6-to-partner and partner-to-MED6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Monoubiquitinated protein deubiquitination grouped by MED6-low versus MED6-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MED6→partner) and Y-score (partner→MED6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Monoubiquitinated protein deubiquitination →	+0.127	+0.816	<.001	<.001	3	14
SOFT_TISSUE	DNA-templated DNA replication →	+0.108	+0.908	<.001	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	Double-strand break repair via synthesis-dependent strand annealing →	+0.102	+0.747	.001	.002	3	13
UPPER_AERODIGESTIVE_TRACT	DNA recombination →	+0.068	+0.867	<.001	<.001	3	13
BLOOD_Leukemia	Positive regulation of mRNA processing →	+0.111	+0.609	<.001	<.001	3	13
SOFT_TISSUE	Regulation of G2/M transition of mitotic cell cycle →	+0.080	+0.781	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,292 associations by consensus.

Monoubiquitinated protein deubiquitination by MED6 expression — SOFT_TISSUE

Explore this box plot interactively →