MED31

Across TCGA patient cohorts, MED31 mutation is significantly associated with the RNA expression of many other genes, with 187 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible MED31-associated genes across cancer lineages are NPM1P14, FABP12, and IGHD2-15. Each is linked with MED31 in more than 1 cancer types. Because this analysis shows association rather than direction, both MED31-to-partner and partner-to-MED31 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NPM1P14 grouped by MED31-low versus MED31-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MED31→partner) and Y-score (partner→MED31) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	NPM1P14 →	+0.298	+3.830	<.001	.002	3	2
UCEC	FABP12 →	+0.194	+2.580	.001	.009	3	2
UCEC	IGHD2-15 →	+2.384	+3.342	<.001	.001	3	2
UCEC	DIP2A-IT1 →	+0.449	+4.015	.002	.001	3	2
UCEC	SEPTIN7P8 →	+0.201	+3.388	<.001	.001	3	2
UCEC	MSANTD2P1 →	+0.100	+3.581	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 187 associations by consensus.

NPM1P14 by MED31 expression — SKCM

Explore this box plot interactively →