MED31

Across TCGA pan-cancer cohorts, MED31 RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of MED31’s most consistent transcriptional readouts.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where MED31 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MED31 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

LIHC, KICH, and HNSC are the cancer types where MED31 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MED31 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LIHC	All	II,III,IV	+0.679	<.001	9	view →
KICH	Female	II,III,IV	−1.594	<.001	7	view →
HNSC	All	III,IV	+0.459	<.001	7	view →
BLCA	All	All	+0.396	.006	6	view →
CHOL	Male	All	+1.388	<.001	5	view →
ESCA	All	All	+0.622	.044	1	view →
COAD	All	II,III,IV	+0.324	.042	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

MED31–LIHC

Open the LIHC breakdown →