MED31

Across TCGA patient cohorts, MED31 mutation is significantly associated with the immune_cell of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MED31-associated genes across cancer lineages are MPP, Skeletal muscle, and aDC. Each is linked with MED31 in more than 1 cancer types. Because this analysis shows association rather than direction, both MED31-to-partner and partner-to-MED31 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MPP grouped by MED31-low versus MED31-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MED31→partner) and Y-score (partner→MED31) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	MPP →	+0.013	+4.694	.008	.014	3	2
UCEC	Skeletal muscle →	+0.060	+3.010	.018	.020	3	2
UCEC	aDC →	+0.103	+3.010	.015	.020	2	1
UCEC	Endothelial cells →	-0.044	-2.957	.048	.037	2	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

MPP by MED31 expression — LUSC

Explore this box plot interactively →