MED31

Across TCGA cell cohorts, MED31 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,249 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MED31-associated GO terms across cancer lineages are Telomere assembly, Regulation of establishment of protein localization to telomere, and Mitochondrial respiratory chain complex IV assembly. Each is linked with MED31 in more than 12 cancer types. Because this analysis shows association rather than direction, both MED31-to-partner and partner-to-MED31 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Telomere assembly grouped by MED31-low versus MED31-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MED31→partner) and Y-score (partner→MED31) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Telomere assembly →	+0.175	+0.808	<.001	<.001	3	13
UPPER_AERODIGESTIVE_TRACT	Regulation of establishment of protein localization to telomere →	+0.108	+0.669	.001	<.001	3	11
SKIN	Mitochondrial respiratory chain complex IV assembly →	+0.068	+0.457	<.001	.004	3	10
BLOOD_Myeloma	Cytochrome complex assembly →	+0.080	+0.828	<.001	.005	3	10
BREAST	Regulation of telomere maintenance via telomerase →	+0.060	+0.646	<.001	.001	2	10
LUNG_SCLC	Cytosolic ciliogenesis →	+0.091	+0.585	.004	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,249 associations by consensus.

Telomere assembly by MED31 expression — BREAST

Explore this box plot interactively →