MED27

Across TCGA patient cohorts, MED27 mutation is significantly associated with the RNA expression of many other genes, with 626 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MED27-associated genes across cancer lineages are RN7SL134P, RNU6-1155P, and RNA5SP325. Each is linked with MED27 in more than 1 cancer types. Because this analysis shows association rather than direction, both MED27-to-partner and partner-to-MED27 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL134P grouped by MED27-low versus MED27-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MED27→partner) and Y-score (partner→MED27) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RN7SL134P →	+0.118	+2.462	.002	.004	3	2
UCEC	RNU6-1155P →	+0.106	+4.253	.005	.004	3	2
UCEC	RNA5SP325 →	+0.898	+1.933	<.001	.009	3	2
UCEC	RNY1P1 →	+0.208	+3.220	<.001	.005	3	2
UCEC	MIR519A1 →	+0.275	+2.602	.005	.006	3	2
UCEC	RNA5SP86 →	+0.512	+2.714	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 626 associations by consensus.

RN7SL134P by MED27 expression — UCEC

Explore this box plot interactively →