MED27

Across TCGA pan-cancer cohorts, MED27 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated MED27 data layer compared with 2 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher MED27 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated MED27 expression acts as an unfavorable survival marker, although some lineages such as CESC and SCLC show a favorable association.

ACC, LIHC, and HNSC are the cancer types where MED27 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.192	0.708	<.001	107	view →
LIHC	OS	Tertile	II,III,IV	0.424	0.780	<.001	52	view →
HNSC	OS	Tertile	All	0.638	0.816	.004	43	view →
COAD	DFS	Quartile	IV	0.311	0.605	.002	43	view →
BLCA	DFS	Median	All	0.480	0.687	.005	42	view →
MESO	OS	Tertile	All	0.431	0.652	.003	42	view →
CESC	DFS	Quartile	All	0.677	0.404	.004	34	view →
SCLC	OS	Tertile	II,III,IV	0.700	0.241	<.001	34	view →
LAML	DFS	Quartile	All	0.429	0.728	.002	34	view →
UCS	OS	Tertile	IV	0.156	1.000	.024	30	view →
CHOL	OS	Tertile	II,III,IV	0.961	0.284	.018	25	view →
SKCM	OS	Tertile	All	0.251	0.427	.001	24	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

MED27–ACC (DFS)

Open the ACC breakdown →