MED27

Across TCGA patient cohorts, MED27 mutation is significantly associated with the immune_cell of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MED27-associated genes across cancer lineages are Monocytes, Pericytes, and CD8+ naive T-cells. Each is linked with MED27 in more than 1 cancer types. Because this analysis shows association rather than direction, both MED27-to-partner and partner-to-MED27 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Monocytes grouped by MED27-low versus MED27-high in LIHC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MED27→partner) and Y-score (partner→MED27) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIHC	Monocytes →	+0.018	+5.305	<.001	.048	3	1
BLCA	Pericytes →	+0.052	+4.173	.002	.027	3	1
UCEC	CD8+ naive T-cells →	+0.024	+2.158	.039	.010	3	1
UCEC	Neurons →	-0.020	-2.094	.014	.019	3	1
UCEC	pDC →	+0.054	+2.329	.010	.020	3	1
UCEC	Plasma cells →	-0.019	-2.072	.045	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

Monocytes by MED27 expression — LIHC

Explore this box plot interactively →