MED26

Across TCGA patient cohorts, MED26 mutation is significantly associated with the RNA expression of many other genes, with 3,320 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MED26-associated genes across cancer lineages are NDUFB4P4, TRAJ12, and RNU4-86P. Each is linked with MED26 in more than 1 cancer types. Because this analysis shows association rather than direction, both MED26-to-partner and partner-to-MED26 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NDUFB4P4 grouped by MED26-low versus MED26-high in LGG.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MED26→partner) and Y-score (partner→MED26) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LGG	NDUFB4P4 →	+0.209	+5.206	<.001	.007	3	2
UCEC	TRAJ12 →	+0.679	+2.340	<.001	<.001	3	2
UCEC	RNU4-86P →	+0.214	+1.735	.008	.004	3	2
UCEC	SIRPG-AS1 →	+0.054	+2.094	.003	<.001	3	2
UCEC	RN7SL191P →	+0.140	+2.155	<.001	.007	3	2
UCEC	RNA5SP417 →	+0.434	+2.071	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,320 associations by consensus.

NDUFB4P4 by MED26 expression — LGG

Explore this box plot interactively →