MED25

Across TCGA patient cohorts, MED25 mutation is significantly associated with the RNA expression of many other genes, with 1,074 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MED25-associated genes across cancer lineages are RNU6-1213P, INSL4, and MIR190A. Each is linked with MED25 in more than 3 cancer types. Because this analysis shows association rather than direction, both MED25-to-partner and partner-to-MED25 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-1213P grouped by MED25-low versus MED25-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MED25→partner) and Y-score (partner→MED25) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	RNU6-1213P →	+0.359	+5.342	<.001	.002	3	4
COAD	INSL4 →	+1.312	+3.127	<.001	.001	3	3
COAD	MIR190A →	+0.169	+3.917	<.001	.009	3	3
UCEC	SFXN1 →	+0.400	+2.343	.003	.003	3	2
UCEC	ZMYND19 →	+0.488	+2.424	<.001	<.001	3	2
UCEC	CENPN →	+0.656	+3.828	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,074 associations by consensus.

RNU6-1213P by MED25 expression — CESC

Explore this box plot interactively →