MED25

Across TCGA pan-cancer cohorts, MED25 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of MED25’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where MED25 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MED25 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

COAD, STAD, and KIRP are the cancer types where MED25 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MED25 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	IV	+0.984	<.001	11	view →
STAD	Male	II,III,IV	+0.958	<.001	10	view →
KIRP	All	III,IV	+0.594	<.001	10	view →
LIHC	Female	II,III,IV	+1.550	<.001	9	view →
HNSC	Male	All	+0.450	<.001	7	view →
BRCA	All	III,IV	+0.877	<.001	6	view →
BLCA	All	All	+0.492	.001	6	view →
CHOL	All	All	+2.460	<.001	5	view →
ESCA	All	All	+0.573	<.001	5	view →
KIRC	Female	All	+0.341	.010	5	view →
THCA	All	II,III,IV	−0.248	.016	4	view →
KICH	All	All	−0.546	.003	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

MED25–COAD

Open the COAD breakdown →