MED25

Across TCGA patient cohorts, MED25 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MED25-associated genes across cancer lineages are MEK1, CDK1, and 4E-BP1. Each is linked with MED25 in more than 1 cancer types. Because this analysis shows association rather than direction, both MED25-to-partner and partner-to-MED25 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by MED25-low versus MED25-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MED25→partner) and Y-score (partner→MED25) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.371	+2.115	.011	.017	3	2
COAD	CDK1 →	+0.353	+2.815	<.001	.036	3	2
COAD	4E-BP1 →	+0.249	+2.815	.038	.036	3	2
UCEC	ERK2 →	+0.156	+2.459	.043	.018	3	1
UCEC	ACC1 →	+0.319	+1.750	.029	.049	3	1
UCEC	JNK_pT183_Y185 →	-0.150	-1.893	.026	.016	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

MEK1 by MED25 expression — UCEC

Explore this box plot interactively →