MED25

Across TCGA cell cohorts, MED25 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,779 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible MED25-associated GO terms across cancer lineages are Negative regulation of calcium ion export across plasma membrane, Negative regulation of RNA splicing, and Negative regulation of mRNA splicing, via spliceosome. Each is linked with MED25 in more than 14 cancer types. Because this analysis shows association rather than direction, both MED25-to-partner and partner-to-MED25 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of calcium ion export across plasma membrane grouped by MED25-low versus MED25-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MED25→partner) and Y-score (partner→MED25) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Negative regulation of calcium ion export across plasma membrane →	+0.091	+0.963	<.001	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	Negative regulation of RNA splicing →	+0.086	+0.689	.002	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	Negative regulation of mRNA splicing, via spliceosome →	+0.107	+0.689	<.001	<.001	3	14
STOMACH	Negative regulation of myoblast fusion →	+0.117	+0.865	.001	.006	3	13
UPPER_AERODIGESTIVE_TRACT	Negative regulation of mRNA processing →	+0.102	+0.689	<.001	<.001	3	13
LARGE_INTESTINE	Regulation of DNA-templated transcription initiation →	+0.053	+0.696	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,779 associations by consensus.

Negative regulation of calcium ion export across plasma membrane by MED25 expression — BREAST

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