MED25

Across TCGA cell cohorts, MED25 mutation is significantly associated with the RNA expression of many other genes, with 33 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MED25-associated genes across cancer lineages are PHOX2B, IQCF5, and CD300H. Each is linked with MED25 in more than 1 cancer types. Because this analysis shows association rather than direction, both MED25-to-partner and partner-to-MED25 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PHOX2B grouped by MED25-low versus MED25-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MED25→partner) and Y-score (partner→MED25) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PHOX2B →	+0.019	+3.365	<.001	.005	3	2
BLOOD_Leukemia	IQCF5 →	+0.061	+3.786	<.001	.002	3	2
OVARY	CD300H →	+0.047	+5.196	<.001	.005	3	2
SKIN	OR2T4 →	+0.019	+4.415	<.001	.007	3	1
BREAST	SIGLECL1 →	+0.020	+4.781	<.001	.003	3	1
STOMACH	TAAR1 →	+0.142	+3.432	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

PHOX2B by MED25 expression — BLOOD_Leukemia

Explore this box plot interactively →