MED23

Across TCGA cell cohorts, MED23 mutation is significantly associated with the RNA expression of many other genes, with 764 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MED23-associated genes across cancer lineages are MEP1A, ACER1, and MAGEB5. Each is linked with MED23 in more than 1 cancer types. Because this analysis shows association rather than direction, both MED23-to-partner and partner-to-MED23 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEP1A grouped by MED23-low versus MED23-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MED23→partner) and Y-score (partner→MED23) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	MEP1A →	+0.711	+4.247	.002	.005	3	2
LARGE_INTESTINE	ACER1 →	+0.065	+3.045	.004	<.001	3	2
LUNG_NSCLC_LUSC	MAGEB5 →	+0.033	+4.643	<.001	.008	3	1
BLOOD_Myeloma	KCNG4 →	+0.013	+4.807	<.001	.006	3	1
OESOPHAGUS	PRRG3 →	+0.334	+4.017	.003	.007	3	1
OESOPHAGUS	CFC1 →	+0.037	+4.857	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 764 associations by consensus.

MEP1A by MED23 expression — LUNG_SCLC

Explore this box plot interactively →