MED22

Across TCGA patient cohorts, MED22 protein abundance is significantly associated with the protein abundance of many other proteins, with 22,685 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible MED22-associated proteins across cancer lineages are RFC4, MED28, and DHX15. Each is linked with MED22 in more than 9 cancer types. Because this analysis shows association rather than direction, both MED22-to-partner and partner-to-MED22 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, MED22 versus RFC4 in LSCC, with a Pearson correlation of 0.64.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (MED22→partner) and Y-score (partner→MED22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RFC4 →	+0.482	+0.273	<.001	<.001	3	10
GBM	MED28 →	+0.401	+0.269	<.001	<.001	3	9
LSCC	DHX15 →	+0.240	+0.361	<.001	<.001	3	8
LSCC	GTF3C4 →	+0.417	+0.300	<.001	<.001	3	8
LSCC	RFC2 →	+0.445	+0.276	<.001	<.001	3	8
GBM	SSRP1 →	+0.442	+0.258	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 22,685 associations by consensus.

MED22 vs RFC4 — LSCC

Explore this scatter interactively →