MED17

Across TCGA patient cohorts, MED17 mutation is significantly associated with the RNA expression of many other genes, with 1,407 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MED17-associated genes across cancer lineages are MIR548C, C1GALT1P3, and MIR3690. Each is linked with MED17 in more than 1 cancer types. Because this analysis shows association rather than direction, both MED17-to-partner and partner-to-MED17 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR548C grouped by MED17-low versus MED17-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MED17→partner) and Y-score (partner→MED17) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	MIR548C →	+0.377	+5.124	.001	.008	3	2
SKCM	C1GALT1P3 →	+0.396	+3.424	<.001	.009	3	2
SKCM	MIR3690 →	+0.574	+3.749	<.001	.001	3	2
LUSC	RNU6-1177P →	+0.383	+3.277	.003	.004	3	2
LUSC	TUBB8P3 →	+0.079	+3.861	<.001	.001	3	2
UCEC	RNA5SP412 →	+0.360	+2.104	.003	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,407 associations by consensus.

MIR548C by MED17 expression — HNSC

Explore this box plot interactively →