MED15

Across TCGA patient cohorts, MED15 RNA expression is significantly associated with the go_rna of many other GO terms, with 7,168 significant associations in total. KIRC shows the largest number of these associations.

The most reproducible MED15-associated GO terms across cancer lineages are Protein import into peroxisome membrane, Negative regulation of type I interferon-mediated signaling pathway, and Negative regulation of protein tyrosine kinase activity. Each is linked with MED15 in more than 25 cancer types. Because this analysis shows association rather than direction, both MED15-to-partner and partner-to-MED15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein import into peroxisome membrane grouped by MED15-low versus MED15-high in LAML.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MED15→partner) and Y-score (partner→MED15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LAML	Protein import into peroxisome membrane →	+0.049	+0.522	<.001	<.001	3	26
SCLC	Negative regulation of type I interferon-mediated signaling pathway →	+0.127	+0.846	.005	.004	2	24
DLBC	Negative regulation of protein tyrosine kinase activity →	+0.076	+0.523	<.001	<.001	3	23
SCLC	Obsolete regulation of histone methylation →	+0.204	+1.168	<.001	<.001	2	24
SCLC	Regulation of establishment of protein localization to mitochondrion →	+0.109	+1.182	<.001	<.001	2	24
DLBC	Protein linear polyubiquitination →	+0.076	+0.561	<.001	<.001	3	22

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,168 associations by consensus.

Protein import into peroxisome membrane by MED15 expression — LAML

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