MED15

Across TCGA pan-cancer cohorts, MED15 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of MED15’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where MED15 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MED15 is over-expressed in tumor.

HNSC, KIRC, and LIHC are the cancer types where MED15 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MED15 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	+1.378	<.001	12	view →
KIRC	Female	All	+0.872	<.001	12	view →
LIHC	Female	II,III,IV	+1.303	<.001	9	view →
KIRP	All	All	+0.514	<.001	9	view →
COAD	All	II,III,IV	+0.265	<.001	8	view →
STAD	Male	All	+0.788	<.001	6	view →
THCA	Male	All	+0.491	<.001	6	view →
CHOL	Male	All	+2.635	<.001	5	view →
LUSC	Male	All	+0.466	<.001	4	view →
BLCA	Female	III,IV	+0.504	.008	3	view →
READ	All	III,IV	+0.519	.028	2	view →
PAAD	Male	All	+0.375	.030	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

MED15–HNSC

Open the HNSC breakdown →