MED15

Across TCGA patient cohorts, MED15 mutation is significantly associated with the RNA expression of many other genes, with 2,425 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MED15-associated genes across cancer lineages are IFNA11P, RNU6-626P, and RNA5SP198. Each is linked with MED15 in more than 1 cancer types. Because this analysis shows association rather than direction, both MED15-to-partner and partner-to-MED15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IFNA11P grouped by MED15-low versus MED15-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MED15→partner) and Y-score (partner→MED15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	IFNA11P →	+0.135	+4.195	.008	.001	3	2
CESC	RNU6-626P →	+0.534	+5.669	<.001	.003	3	2
CESC	RNA5SP198 →	+0.374	+6.144	<.001	.001	3	2
BRCA	RNU6-933P →	+0.399	+3.369	<.001	.004	3	2
SKCM	ATG7 →	+0.385	+3.247	.009	.008	3	2
SKCM	RNA5SP213 →	+0.104	+4.488	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,425 associations by consensus.

IFNA11P by MED15 expression — BRCA

Explore this box plot interactively →