MED15

Across TCGA patient cohorts, MED15 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MED15-associated genes across cancer lineages are Caspase-7-cleavedD198, 4E-BP1, and eIF4E. Each is linked with MED15 in more than 2 cancer types. Because this analysis shows association rather than direction, both MED15-to-partner and partner-to-MED15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by MED15-low versus MED15-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MED15→partner) and Y-score (partner→MED15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.675	+2.019	<.001	.005	3	3
UCEC	4E-BP1 →	+0.382	+2.936	<.001	<.001	3	3
UCEC	eIF4E →	+0.238	+4.000	<.001	<.001	2	3
UCEC	Annexin-1 →	+0.717	+2.604	<.001	<.001	3	2
UCEC	CD49b →	-0.218	-1.787	.024	.026	3	2
UCEC	14-3-3_beta →	-0.087	-1.973	.011	.029	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

Caspase-7-cleavedD198 by MED15 expression — UCEC

Explore this box plot interactively →