MED15

Across TCGA cell cohorts, MED15 mutation is significantly associated with the RNA expression of many other genes, with 769 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MED15-associated genes across cancer lineages are CLEC6A, MAGEB5, and FAM236A. Each is linked with MED15 in more than 1 cancer types. Because this analysis shows association rather than direction, both MED15-to-partner and partner-to-MED15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CLEC6A grouped by MED15-low versus MED15-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MED15→partner) and Y-score (partner→MED15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	CLEC6A →	+0.126	+5.029	<.001	.006	3	1
LUNG_NSCLC_LUSC	MAGEB5 →	+0.033	+4.643	<.001	.008	3	1
UPPER_AERODIGESTIVE_TRACT	FAM236A →	+0.120	+5.357	<.001	.003	3	1
SKIN	SLC35G3 →	+0.017	+4.415	<.001	.007	3	1
LARGE_INTESTINE	SNRPD3 →	+0.432	+2.743	.005	.001	3	1
LARGE_INTESTINE	GGA1 →	+0.543	+2.043	.005	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 769 associations by consensus.

CLEC6A by MED15 expression — LUNG_SCLC

Explore this box plot interactively →