MED14

Across TCGA patient cohorts, MED14 mutation is significantly associated with the RNA expression of many other genes, with 5,019 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MED14-associated genes across cancer lineages are C16orf70, PARP2, and CYB5D1. Each is linked with MED14 in more than 3 cancer types. Because this analysis shows association rather than direction, both MED14-to-partner and partner-to-MED14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C16orf70 grouped by MED14-low versus MED14-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MED14→partner) and Y-score (partner→MED14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C16orf70 →	+0.426	+1.450	<.001	<.001	3	4
UCEC	PARP2 →	+0.477	+2.201	<.001	<.001	3	4
COAD	CYB5D1 →	+0.571	+3.362	<.001	.005	3	3
UCEC	BRD2 →	+0.345	+1.472	<.001	<.001	3	3
UCEC	NEURL4 →	+0.382	+1.595	<.001	<.001	3	3
UCEC	RNU2-27P →	+0.724	+2.818	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,019 associations by consensus.

C16orf70 by MED14 expression — UCEC

Explore this box plot interactively →