MED14

Across TCGA patient cohorts, MED14 mutation is significantly associated with the total protein of many other genes, with 51 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MED14-associated genes across cancer lineages are 14-3-3_beta, Rab25, and XBP1. Each is linked with MED14 in more than 2 cancer types. Because this analysis shows association rather than direction, both MED14-to-partner and partner-to-MED14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by MED14-low versus MED14-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MED14→partner) and Y-score (partner→MED14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.075	-1.487	.005	.012	3	3
COAD	Rab25 →	-0.421	-3.000	.001	.035	3	2
COAD	XBP1 →	+0.418	+3.000	<.001	.034	3	2
UCEC	EGFR_pY1068 →	-0.172	-1.000	.010	.026	3	2
UCEC	ERK2 →	+0.137	+1.000	.008	.026	3	2
UCEC	Heregulin →	-0.083	-1.234	.012	.038	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

14-3-3_beta by MED14 expression — UCEC

Explore this box plot interactively →