MED14

Across TCGA cell cohorts, MED14 mutation is significantly associated with the RNA expression of many other genes, with 95 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible MED14-associated genes across cancer lineages are CTXN3, NAA11, and OR52L1. Each is linked with MED14 in more than 2 cancer types. Because this analysis shows association rather than direction, both MED14-to-partner and partner-to-MED14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CTXN3 grouped by MED14-low versus MED14-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MED14→partner) and Y-score (partner→MED14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CTXN3 →	+0.007	+4.201	<.001	.001	3	3
LARGE_INTESTINE	NAA11 →	+0.310	+3.706	.002	.002	3	2
BLOOD_Lymphoma	OR52L1 →	+0.081	+4.606	<.001	.001	3	2
BLOOD_Leukemia	ZIC3 →	+0.012	+3.475	<.001	.006	3	2
LUNG_NSCLC_LUAD	COX4I2 →	+0.095	+5.228	<.001	.005	3	1
LARGE_INTESTINE	SNPH →	+1.092	+3.215	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 95 associations by consensus.

CTXN3 by MED14 expression — BLOOD_Leukemia

Explore this box plot interactively →