MED13

Across TCGA patient cohorts, MED13 mutation is significantly associated with the RNA expression of many other genes, with 6,766 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MED13-associated genes across cancer lineages are GCH1, DSCR8, and FEN1. Each is linked with MED13 in more than 4 cancer types. Because this analysis shows association rather than direction, both MED13-to-partner and partner-to-MED13 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GCH1 grouped by MED13-low versus MED13-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MED13→partner) and Y-score (partner→MED13) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GCH1 →	+0.743	+2.059	<.001	<.001	3	5
READ	DSCR8 →	+1.411	+3.909	.001	.007	3	4
UCEC	FEN1 →	+0.620	+1.797	<.001	<.001	3	4
SKCM	AURKB →	+0.601	+2.906	.002	.001	3	4
UCEC	PRC1 →	+0.633	+1.415	<.001	<.001	3	4
UCEC	LINC02195 →	+0.693	+1.797	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,766 associations by consensus.

GCH1 by MED13 expression — UCEC

Explore this box plot interactively →