MED13

Across TCGA pan-cancer cohorts, MED13 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of MED13’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where MED13 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MED13 is over-expressed in tumor, although a few such as KICH and UCEC show the opposite, repressed pattern.

HNSC, THCA, and BLCA are the cancer types where MED13 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MED13 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.760	<.001	10	view →
THCA	All	II,III,IV	+0.610	<.001	9	view →
BLCA	All	All	+0.602	<.001	9	view →
KICH	Female	All	−1.199	<.001	7	view →
LIHC	All	All	+0.542	<.001	7	view →
STAD	All	II,III,IV	+0.781	<.001	6	view →
BRCA	All	II,III,IV	+0.423	<.001	6	view →
CHOL	Male	All	+1.424	<.001	5	view →
LUAD	All	All	+0.314	.007	5	view →
KIRP	Female	All	+0.573	.009	4	view →
UCEC	All	All	−0.440	.028	2	view →
LUSC	All	All	+0.241	.017	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

MED13–HNSC

Open the HNSC breakdown →