MED13

Across TCGA patient cohorts, MED13 mutation is significantly associated with the total protein of many other genes, with 48 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MED13-associated genes across cancer lineages are Caspase-7-cleavedD198, eIF4E, and Notch1. Each is linked with MED13 in more than 3 cancer types. Because this analysis shows association rather than direction, both MED13-to-partner and partner-to-MED13 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by MED13-low versus MED13-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MED13→partner) and Y-score (partner→MED13) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.694	+1.415	<.001	<.001	3	4
UCEC	eIF4E →	+0.178	+1.691	<.001	<.001	3	4
UCEC	Notch1 →	+0.117	+1.039	<.001	.008	3	3
BLCA	c-Kit →	-0.264	-2.584	.025	.010	3	2
UCEC	EGFR_pY1068 →	-0.219	-1.415	<.001	<.001	3	2
UCEC	GAPDH →	+0.296	+1.392	.026	.015	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

Caspase-7-cleavedD198 by MED13 expression — UCEC

Explore this box plot interactively →