MED13

Across TCGA cell cohorts, MED13 mutation is significantly associated with the RNA expression of many other genes, with 192 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MED13-associated genes across cancer lineages are CLPS, UCMA, and TMEM268. Each is linked with MED13 in more than 1 cancer types. Because this analysis shows association rather than direction, both MED13-to-partner and partner-to-MED13 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CLPS grouped by MED13-low versus MED13-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MED13→partner) and Y-score (partner→MED13) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	CLPS →	+0.114	+4.977	<.001	.002	3	2
BLOOD_Leukemia	UCMA →	+0.055	+3.189	<.001	.002	3	2
LARGE_INTESTINE	TMEM268 →	+0.720	+3.502	.001	.001	3	2
LARGE_INTESTINE	ZBTB21 →	+0.623	+2.451	<.001	.009	3	2
LARGE_INTESTINE	PBOV1 →	+0.044	+2.562	.003	.007	3	2
SOFT_TISSUE	HOXB1 →	+0.010	+4.222	.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 192 associations by consensus.

CLPS by MED13 expression — SOFT_TISSUE

Explore this box plot interactively →